Buy Cytotec Now Purpose in USA and Canada
Compare the ability of blockers of histamine H2-receptor and Cytotec to prevent damage of the mucous of the gastrointestinal tract caused by nonsteroidal anti-inflammatory drugs (NSAIDs).
Sources of information
Database MEDLINE (1970 to December 1994) - Search by keyword: non-steroidal anti-inflammatory drugs, ulcer, duodenal ulcer disease or peptic ulcers, prevention, randomized controlled trials; antagonists (blockers) H2-receptors, Cytotec. References in review articles on the subject. Study selection
Randomized controlled trials in which the efficiency of H2-receptor blockers or Cytotec compared with placebo in osteoarthritis, rheumatoid arthritis or in healthy subjects. Inclusion criteria also included: the implementation of endoscopy prior to and during the reception of NSAIDs, lack of ulcers in the first endoscopic examination, taking NSAIDs for? 5 days.
Data Selection Buy Cytotec Online cheap Source risk of mucosa of the gastrointestinal tract associated with short (<2 weeks) or prolonged (> 4 weeks) taking NSAIDs, the number of patients in whom there sores or lesions (defined as a single ulcer or> 5 erosions) of the stomach or duodenum ; methodological features of the study.
Main results Buy Cytotec without prescription Meet the selection criteria 24 studies (4,325 patients). At short-term NSAID receiving the appointment of Cytotec reduces the risk of stomach ulcers compared with placebo (p <0,05). Absolute risk reduction (SAR) of 13% means that for the prevention of gastric ulcers in 1 patient a short-term course of Cytotec (not placebo) must be assigned to 8 patients, 95% confidence interval (CI) from 4 to 112. Similar results were obtained for the longer course of treatment (p <0,001; SAR = 8%, the number of patients needed to treat to prevent gastric ulcers in 1 patient, was 12 CI 6 to 100). Short-term and long-term use of H2-receptor blockers did not reduce the risk of stomach ulcers. Chronic administration of NSAIDs as Cytotec and H2-receptor blockers (as opposed to placebo) reduced the risk of duodenal ulcers (p <0,001 and p = 0.04 resp.). Cytotec for ATS was 3% and the number of patients needed to treat for prevention of duodenal ulcers in 1 patient, was 30, CI 18 to 1000. For the H2-receptor blockers SAR was 2% and the number of patients needed to treat for prevention of duodenal ulcers in 1 patient was equal to 42, with CI of 22 to 500. However, when short-term NSAID receiving Cytotec and H2-receptor blockers do not reduce the risk of duodenal ulcers. For Cytotec SAR was 2%, CI -1.6 to 5.7% for the H2-receptor blockers - 1% CI -5 to 3%. Cytotec reduced the risk of damage to gastric mucosa and duodenum as in the short-term and chronic administration of NSAIDs (p <0.001 in both cases). H2-receptor blockers affect the frequency of lesions of the stomach and duodenum as well as placebo.
Conclusions Cytotec reduces the risk of stomach ulcers, and H2-receptor blockers have no effect on him. As Cytotec and H2-receptor blockers prevent the development of duodenal ulcers resulting from chronic administration of NSAIDs.
Source of funding: not installed. Buy Cytotec Now Address for correspondence: Dr. M. Koch, Department of Digestive Diseases and Nutrition, General Hospital San Filippo Neri, Via Martinotti 20, 00135 Rome, Italy. FAX 39-6-338-0217.